TaRGET 2a

Exposure Timing, Tissue and Cell Specific Epigenomics and Lifecourse Phenotypes. 

Toxicant exposures early in life adversely affect health outcomes later in life in animals and humans, in part due to epigenetic mechanisms, including DNA methylation. Many epigenetic epidemiology analyses are performed using biologically available DNA (e.g. blood, saliva, stool), which serve as proxies for epigenetic status in tissues targeted by exposures. Thus, the goal of the Target II U01 is to utilize an established mouse model of environmental exposures to evaluate tissue- and cell-specific epigenetic alterations associated with perinatal exposures and disease outcomes. Role: Principal Investigator  

NIEHS Environmental Factor Blog on TarGET II: http://www.niehs.nih.gov/news/newsletter/2016/6/science-highlights/target/index.htm

TaRGET 2b- Supplement for Whole Genome Bisulfite Sequencing (WGBS)

The University of Michigan site will oversee and conduct whole genome-bisulfite sequencing for the TaRGET II consortium. Role: Principal Investigator